How to Bill CPT 88300 for Pathology and Laboratory Services

When to Use CPT Code 88300

CPT 88300 is used for pathology or laboratory diagnostic services, including specimen examination, interpretation, and reporting.

• •Service type: Pathology / laboratory services
• •Specimen: Tissue, cytology, blood, or molecular sample
• •Who bills it: Pathologists and clinical laboratories

Common scenarios:

• •Surgical pathology examination
• •Cytology interpretation
• •Hematopathology consultation
• •Molecular diagnostic testing

Insurance Verification Tips for CPT 88300

1. •Confirm specimen type and complexity level.
2. •Verify bundling and component billing rules.
3. •Ensure documentation supports medical necessity.
4. •Check payer policies for molecular diagnostics.

Example Case of CPT 88300

A specimen is analyzed by a laboratory or pathologist and a diagnostic report is generated.
The service is billed as one unit of CPT 88300.